A sphingolipid
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C26 Ceramide (d18:1/26:0) (synthetic)

Item No. 42978

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-hexacosanamide
CAS Number
121459-09-4
Synonyms
  • Cer(d18:1/26:0)
  • Ceramide (d18:1/26:0)
  • N-Hexacosanoyl-D-erythro-Sphingosine
Molecular Formula
C44H87NO3
Formula Weight
678.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: soluble
SMILES
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(CCCCCCCCCCCCCCCCCCCCCCCCC)=O)CO
InChi Code
InChI=1S/C44H87NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-28-30-32-34-36-38-40-44(48)45-42(41-46)43(47)39-37-35-33-31-29-27-16-14-12-10-8-6-4-2/h37,39,42-43,46-47H,3-36,38,40-41H2,1-2H3,(H,45,48)/b39-37+/t42-,43+/m0/s1
InChi Key
CJROVRTUSFQVMR-GVOPMEMSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $164

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    Product Description

    C26 Ceramide is an endogenous ceramide.1 C26 Ceramide levels are increased in tumor tissues from patients with hepatocellular carcinoma (HCC) compared to normal liver tissues.2 C26 ceramide levels are also increased in acid ceramidase deficiency, a lysosomal disorder characterized by developmental delay, myoclonic seizures, and hematological abnormalities.3 This product is fully synthetic and has no variations in the fatty acyl chain or sphingoid backbone. [Matreya, LLC. Catalog No. 1337]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shin, K.-O., Kim, S., Park, B.D., et al. N-Palmitoyl serinol stimulates ceramide production through a CB1-dependent mechanism in in vitro model of skin inflammation. Int. J. Mol. Sci. 22(15), 8302 (2021).

    2. Miura, K., Nagahashi, M., Prasoon, P., et al. Dysregulation of sphingolipid metabolic enzymes leads to high levels of sphingosine-1-phosphate and ceramide in human hepatocellular carcinoma. Hepatol. Res. 51(5), 614-626 (2021).

    3. Mahmoud, I.G., Elmonem, M.A., Zaki, M.S., et al. ASAH1-related disorders: Description of 15 novel pediatric patients and expansion of the clinical phenotype. Clin. Genet. 98(6), 598-605 (2020).