A peptide fragment of nociceptin and a NOP receptor 1 ligand
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Nociceptin (1-11) (human, mouse, rat, porcine, bovine)

Item No. 43006

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanine
CAS Number
178249-41-7
Synonyms
  • OFQ/N (1-11)
  • Orphanin FQ
Molecular Formula
C49H75N15O14
Formula Weight
1098.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
FGGFTGARKSA-OH
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
OC([C@H](C)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC(CNC([C@H]([C@H](O)C)NC([C@@H](NC(CNC(CNC([C@@H](N)CC1=CC=CC=C1)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C49H75N15O14/c1-27(41(70)61-34(18-12-20-54-49(52)53)43(72)62-33(17-10-11-19-50)44(73)63-36(26-65)46(75)59-28(2)48(77)78)58-38(68)25-57-47(76)40(29(3)66)64-45(74)35(22-31-15-8-5-9-16-31)60-39(69)24-55-37(67)23-56-42(71)32(51)21-30-13-6-4-7-14-30/h4-9,13-16,27-29,32-36,40,65-66H,10-12,17-26,50-51H2,1-3H3,(H,55,67)(H,56,71)(H,57,76)(H,58,68)(H,59,75)(H,60,69)(H,61,70)(H,62,72)(H,63,73)(H,64,74)(H,77,78)(H4,52,53,54)/t27-,28-,29+,32-,33-,34-,35-,36-,40-/m0/s1
InChi Key
BBTOUBACUUPBRQ-KCKZSKPYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $174

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    10 mg

    $279

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    25 mg

    $653

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    50 mg

    $1,217

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    Product Description

    Nociceptin (1-11) is a peptide fragment of nociceptin (Item No. 15070) and a ligand for the nociceptin opioid peptide (NOP) receptor. It binds NOP receptor 1 (Ki = 1.3 µM).1 Nociceptin (1-11) inhibits forskolin-induced cAMP accumulation in CHO cells expressing NOP receptor 1 (EC50 = 3.4 µM). It (5 or 10 µg) increases the latency to tail withdrawal from a radiant heat source in a rat model of neuropathic pain when administered at doses of 5 or 10 µg, i.c.v.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Butour, J.L., Moisand, C., Mazarguil, H., et al. Recognition and activation of the opioid receptor-like ORL 1 receptor by nociceptin, nociceptin analogs and opioids. Eur. J. Pharmacol. 321(1), 97-103 (1997).

    2. Rossi, G.C., Perlmutter, M., Leventhal, L., et al. Orphanin FQ/nociceptin analgesia in the rat. Brain Res. 792(2), 327-330 (1998).