An ether-containing ionizable cationic lipid
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Lipid ND-O1

Item No. 43010

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
heptadecan-9-yl 8-((8-(2-(hexyloxy)ethoxy)-8-oxooctyl)(2-hydroxyethyl)amino)octanoate
CAS Number
3096665-79-8
Synonyms
  • SM-86 Analog-2
Molecular Formula
C43H85NO6
Formula Weight
712.2
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCCCC(OCCOCCCCCC)=O)CCO
InChi Code
InChI=1S/C43H85NO6/c1-4-7-10-13-17-23-30-41(31-24-18-14-11-8-5-2)50-43(47)33-26-20-16-22-28-35-44(36-37-45)34-27-21-15-19-25-32-42(46)49-40-39-48-38-29-12-9-6-3/h41,45H,4-40H2,1-3H3
InChi Key
AJCULPGBAFPOED-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $65

    Add

    5 mg

    $260

    Add

    10 mg

    $488

    Add
    Cayman Chemical
    Ionizable Lipids – Your Path from R&D to GMP

    Seamlessly bridge your LNP discovery journey from RUO to bulk GLP-tox and GMP excipient-grade material.

    Explore CGMP Lipid Services
    Product Description

    Lipid ND-O1 is an ether-containing ionizable cationic lipid (pKa = 6.6) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vitro and in vivo.1 LNPs containing ND-O1 and encapsulating Cy5-labeled siRNA selectively accumulate in the liver over the spleen, heart, kidney, and lung in mice. LNPs containing ND-O1 and encapsulating siRNA targeting heat shock protein 47 (Hsp47) decrease hepatic collagen, TNF-α, IL-1β, TGF-β, and IL-6 levels in a mouse model of hepatic fibrosis induced by carbon tetrachloride (CCL4).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chu, R., Kong, J., Gao, Q., et al. Ether bond-modified lipid nanoparticles for enhancing the treatment effect of hepatic fibrosis. Int. J. Pharm. 671, 125192 (2025).