A MAO-B inhibitor and Nrf2 inducer
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

(E)-3-(2-Fluorophenyl)-N-(1H-indol-5-yl)acrylamide

Item No. 43022

Product Insert (PDF)
Technical Information
Formal Name
3-(2-fluorophenyl)-N-1H-indol-5-yl-(2E)-propenamide
CAS Number
3094045-97-0
Synonyms
  • MAO-B inhibitor and NRF2 Inducers Compound 11
Molecular Formula
C17H13FN2O
Formula Weight
280.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NC1=CC2=C(NC=C2)C=C1)/C=C/C3=CC=CC=C3F
InChi Code
InChI=1S/C17H13FN2O/c18-15-4-2-1-3-12(15)5-8-17(21)20-14-6-7-16-13(11-14)9-10-19-16/h1-11,19H,(H,20,21)/b8-5+
InChi Key
CFABHPJGQKBQQS-VMPITWQZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $32

    Add

    5 mg

    $152

    Add

    10 mg

    $288

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    (E)-3-(2-Fluorophenyl)-N-(1H-indol-5-yl)acrylamide is an inhibitor of monoamine oxidase B (MAO-B) and an inducer of nuclear factor erythroid 2-related factor 2 (Nrf2).1 It inhibits MAO-B (IC50 = 3.61 µM) and increases levels of Nrf2 in a reporter assay using AREc32 cells (IC50 = 0.361 µM). (E)-3-(2-Fluorophenyl)-N-(1H-indol-5-yl)acrylamide scavenges peroxyl radicals in an oxygen radical absorbance capacity (ORAC) assay (IC50 = 2.77 µM) and inhibits LPS-induced increases in nitrite levels in BV-2 microglial cells (EC50 = 11.6 µM). It inhibits 6-OHDA- or rotenone- and oligomycin A-induced decreases in viability in SH-SY5Y neuroblastoma cells when used at a concentration of 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Duarte, P., Sanchez-Porro, F.J., Crisman, E., et al. Network-based drug optimization toward the treatment of Parkinson’s disease: NRF2, MAO-B, oxidative stress, and chronic neuroinflammation. J. Med. Chem. 68(3), 3495-3517 (2025).