A molecular glue
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Proteolysis
Ubiquitin/Proteasome System

PT-179

Item No. 43028

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,6-dioxo-3-piperidinyl)-5-(4-morpholinyl)-1H-isoindole-1,3(2H)-dione
CAS Number
2924858-25-1
Molecular Formula
C17H17N3O5
Formula Weight
343.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C1C2=CC=C(N3CCOCC3)C=C2C(N1C4C(NC(CC4)=O)=O)=O
InChi Code
InChI=1S/C17H17N3O5/c21-14-4-3-13(15(22)18-14)20-16(23)11-2-1-10(9-12(11)17(20)24)19-5-7-25-8-6-19/h1-2,9,13H,3-8H2,(H,18,21,22)
InChi Key
CCCSRHUSXCBFJZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $94

    Add

    10 mg

    $179

    Add

    25 mg

    $422

    Add

    50 mg

    $748

    Add
    Product Description

    PT-179 is a molecular glue and ligand for the E3 ubiquitin ligase cereblon.1 It has been used in conjunction with the zinc finger degron SD40 to induce degradation of SD40-tagged proteins.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mercer, J.A.M., DeCarlo, S.J., Roy Burman, S.S., et al. Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science 383(6688), eadk4422 (2024).