A POLRMT inhibitor
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IMT1

Item No. 43029

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-propanamide
CAS Number
2304621-31-4
Synonyms
  • LDC-195943
Molecular Formula
C21H21NO4
Formula Weight
351.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CC1=C(C(C2=C(O3)C=C(OC(C(N(C)C)=O)C)C=C2)=CC3=O)C=CC=C1
InChi Code
InChI=1S/C21H21NO4/c1-13-7-5-6-8-16(13)18-12-20(23)26-19-11-15(9-10-17(18)19)25-14(2)21(24)22(3)4/h5-12,14H,1-4H3
InChi Key
DBIPGWVTQBAHGP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $86

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    10 mg

    $163

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    25 mg

    $387

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    50 mg

    $730

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    Cayman Chemical
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    Product Description

    IMT1 is an inhibitor of mitochondrial RNA polymerase (POLRMT).1 It selectively inhibits POLRMT transcription over six other RNA polymerases at 1 µM. IMT1 (0.05-10 µM) decreases mitochondrial mRNA transcripts and mitochondrial DNA levels in HeLa cervical cancer cells. It reduces oxygen flux in HeLa cells when used at concentrations of 0.5, 1, or 5 µM. IMT1 (0.1 µM) decreases the levels of dATP, dCTP, and dTTP and the levels of citric acid cycle intermediates in A2780 ovarian cancer cells. It decreases tumor volume in an A2780 mouse xenograft model when administered at a dose of 100 mg/kg per day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bonekamp, N.A., Peter, B., Hillen, H.S., et al. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature 588(7839), 712-716 (2020).