A peptide NK2 receptor agonist
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Neuropeptide γ (trifluoroacetate salt)

Item No. 43052

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-alanylglycyl-L-histidylglycyl-L-glutaminyl-L-isoleucyl-L-seryl-L-histidyl-L-lysyl-L-arginyl-L-histidyl-L-lysyl-L-threonyl-L-α-aspartyl-L-seryl-L-phenylalanyl-L-valylglycyl-L-leucyl-L-methioninamide, trifluoroacetate salt
Synonyms
  • γ-Neuropeptide
  • NPG
  • γ-PPT (72-92)
  • γ-Preprotachykinin-1 (72-92)
Molecular Formula
C99H158N34O29S • XCF3COOH
Formula Weight
2320.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
DAGHGQISHKRHKTDSFVGLM-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS pH 7.2: Soluble: ≥10 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@@H](CCC(N)=O)C(N[C@]([C@H](CC)C)([H])C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)=O)CC1=CC=CC=C1)=O)=O)CC(O)=O)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)=O)CC4=CN=CN4)=O)=O)C)=O)CC(O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C99H158N34O29S.C2HF3O2/c1-10-51(6)79(132-88(152)63(24-25-72(103)137)118-73(138)42-112-84(148)66(33-55-38-107-46-114-55)120-74(139)41-111-82(146)52(7)117-83(147)58(102)36-76(141)142)97(161)130-71(45-135)95(159)127-68(35-57-40-109-48-116-57)91(155)123-60(21-14-16-27-100)85(149)122-62(23-18-29-110-99(105)106)86(150)126-67(34-56-39-108-47-115-56)90(154)124-61(22-15-17-28-101)87(151)133-80(53(8)136)98(162)128-69(37-77(143)144)92(156)129-70(44-134)94(158)125-65(32-54-19-12-11-13-20-54)93(157)131-78(50(4)5)96(160)113-43-75(140)119-64(31-49(2)3)89(153)121-59(81(104)145)26-30-163-9;3-2(4,5)1(6)7/h11-13,19-20,38-40,46-53,58-71,78-80,134-136H,10,14-18,21-37,41-45,100-102H2,1-9H3,(H2,103,137)(H2,104,145)(H,107,114)(H,108,115)(H,109,116)(H,111,146)(H,112,148)(H,113,160)(H,117,147)(H,118,138)(H,119,140)(H,120,139)(H,121,153)(H,122,149)(H,123,155)(H,124,154)(H,125,158)(H,126,150)(H,127,159)(H,128,162)(H,129,156)(H,130,161)(H,131,157)(H,132,152)(H,133,151)(H,141,142)(H,143,144)(H4,105,106,110);(H,6,7)/t51-,52-,53+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,78-,79-,80-;/m0./s1
InChi Key
KTWSSODXARVOSK-SHPBOCGVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Neuropeptide γ is a peptide agonist of the neurokinin-2 (NK2) receptor.1 It induces phosphatidylinositol turnover in hamster urinary bladder preparations (EC50 = 7.1 nM) and smooth muscle contractions in isolated hamster bladder (EC50 = 112 nM). Neuropeptide γ selectively binds to NK2 receptors over NK1 and NK3 receptors (IC50s = 0.2, 3.16, and 50.1 nM, respectively). It induces salivation in rats in a dose-dependent manner.2 Intrathecal administration of neuropeptide γ (0.078-78 nmol/animal) increases blood pressure and heart rate in conscious rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van Giersbergen, P.L., Shatzer, S.A., Burcher, E., et al. Comparison of the effects of neuropeptide K and neuropeptide γ with neurokinin A at NK2 receptors in the hamster urinary bladder. Naunyn Schmiedebergs Arch. Pharmacol. 345(1), 51-56 (1992).

    2. Takeda, Y., and Krause, J.E. γ-Preprotachykinin-(72-92)-peptide amide potentiates substance P-induced salivation. Eur. J. Pharmacol. 161(2-3), 267-271 (1989).

    3. Poulat, P., de Champlain, J., and Couture, R. Cardiovascular responses to intrathecal neuropeptide γ in conscious rats: Receptor characterization and mechanism of action. Br. J. Pharmacol. 117(2), 250-257 (1996).