A tachykinin neuropeptide and NK1 receptor agonist
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Hemokinin 1 (mouse, rat) (trifluoroacetate salt)

Item No. 43053

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-seryl-L-arginyl-L-threonyl-L-arginyl-L-glutaminyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl-L-methioninamide, trifluoroacetate salt
Synonyms
  • Arg-Ser-Arg-Thr-Arg-Gln-Phe-Tyr-Gly-Leu-Met-NH2
Molecular Formula
C61H100N22O15S • XCF3COOH
Formula Weight
1413.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
RSRTRQFYGLM-NH2
Solubility(Learn about Variance in Solubility)
PBS pH 7.2: Slightly soluble: 0.1-1 mg/ml
SMILES
OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C61H100N22O15S.C2HF3O2/c1-32(2)27-42(55(95)76-38(49(64)89)22-26-99-4)75-47(88)30-74-51(91)43(29-35-16-18-36(86)19-17-35)80-56(96)44(28-34-11-6-5-7-12-34)81-53(93)41(20-21-46(63)87)78-52(92)39(14-9-24-72-60(67)68)79-58(98)48(33(3)85)83-54(94)40(15-10-25-73-61(69)70)77-57(97)45(31-84)82-50(90)37(62)13-8-23-71-59(65)66;3-2(4,5)1(6)7/h5-7,11-12,16-19,32-33,37-45,48,84-86H,8-10,13-15,20-31,62H2,1-4H3,(H2,63,87)(H2,64,89)(H,74,91)(H,75,88)(H,76,95)(H,77,97)(H,78,92)(H,79,98)(H,80,96)(H,81,93)(H,82,90)(H,83,94)(H4,65,66,71)(H4,67,68,72)(H4,69,70,73);(H,6,7)/t33-,37+,38+,39+,40+,41+,42+,43+,44+,45+,48+;/m1./s1
InChi Key
ITKJSMRARYFITA-IXIJGXLCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $43

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    5 mg

    $194

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    10 mg

    $301

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    25 mg

    $644

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    Product Description

    Hemokinin 1 is an 11-amino acid tachykinin neuropeptide with roles in pain transmission and inflammation and is a neurokinin-1 (NK1) receptor agonist.1,2 It is primarily expressed in immune cells and, to a lesser extent, in the brain.3 Hemokinin 1 binds to NK1 receptors (Ki = 0.175 nM) and induces contractions in isolated rat urinary bladder (EC50 = 100 nM).1 Knockdown of Tac4, the gene encoding hemokinin 1, inhibits neurogenic inflammation-induced mechanical and thermal hypersensitivity and visceral nocifensive behavior in mice.3 Tac4-/- mice also exhibit impaired inflammatory responses to intranasal administration of E. coli LPS.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bellucci, F., Carini, F., Catalani, C., et al. Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br. J. Pharmacol. 135(1), 266-274 (2002).

    2. Agaeva, G.A., Agaeva, U.T., and Godjaev, N.M. The spatial organization of the human hemokinin-1 and mouse/rat hemokinin-1 molecules. Biophysics 60(3), 365-377 (2015).

    3. Hunyady, Á., Hajna, Z., Gubányi, T., et al. Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms. Brain Res. Bull. 147, 165-173 (2019).

    4. Hajna, Z., Borbély, É., Kemény, Á., et al. Hemokinin-1 is an important mediator of endotoxin-induced acute airway inflammation in the mouse. Peptides 64, 1-7 (2015).