An NK3 receptor peptide agonist
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Scyliorhinin II (trifluoroacetate salt) (dogfish)

Item No. 43056

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclic (7→13)-disulfide L-seryl-L-prolyl-L-seryl-L-asparaginyl-L-seryl-L-lysyl-L-cysteinyl-L-prolyl-L-α-aspartylglycyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-valylglycyl-L-leucyl-L-ethioninamide, trifluoroacetate salt
Synonyms
  • SCYII
  • SCY2
  • Scyliorhinin 2
Molecular Formula
C77H119N21O26S3 • XCF3COOH
Formula Weight
1851.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
SPSNSK-[CPDGPDC]-FVGLM-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
O=C([C@H](CSSC[C@H](NC([C@@H](N1)CC(O)=O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)=O)CC2=CC=CC=C2)=O)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CCC3)N3C([C@@H](N)CO)=O)=O)=O)=O)=O)=O)N4[C@@](C(N[C@H](C(NCC(N(CCC5)[C@]5([H])C1=O)=O)=O)CC(O)=O)=O)([H])CCC4.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C77H119N21O26S3.C2HF3O2/c1-38(2)26-44(65(112)85-42(62(81)109)20-25-125-5)84-57(103)31-82-75(122)61(39(3)4)95-68(115)45(27-40-14-7-6-8-15-40)87-71(118)51-36-126-127-37-52(77(124)98-24-13-19-55(98)73(120)89-47(29-59(105)106)63(110)83-32-58(104)96-22-11-17-53(96)72(119)90-48(30-60(107)108)67(114)93-51)94-64(111)43(16-9-10-21-78)86-69(116)49(34-100)91-66(113)46(28-56(80)102)88-70(117)50(35-101)92-74(121)54-18-12-23-97(54)76(123)41(79)33-99;3-2(4,5)1(6)7/h6-8,14-15,38-39,41-55,61,99-101H,9-13,16-37,78-79H2,1-5H3,(H2,80,102)(H2,81,109)(H,82,122)(H,83,110)(H,84,103)(H,85,112)(H,86,116)(H,87,118)(H,88,117)(H,89,120)(H,90,119)(H,91,113)(H,92,121)(H,93,114)(H,94,111)(H,95,115)(H,105,106)(H,107,108);(H,6,7)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,61-;/m0./s1
InChi Key
VQTIVRODJVVFQG-JKVSPIOXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Scyliorhinin II is a neurokinin-3 (NK3) receptor peptide agonist that has been found in dogfish intestines.1 It binds NK3 receptors in isolated rat cerebral cortex (Ki = 2.5 nM). Scyliorhinin II induces contractions in isolated and perfused carp intestinal bulb smooth muscle strips (EC50 = 39 nM).2 It induces reciprocal hindlimb neck-scratching behavior in mice (ED50 = 0.08 nmol/animal, i.c.v.).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buck, S.H., and Krstenansky, J.L. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur. J. Pharmacol. 144(1), 109-111 (1987).

    2. Kitazawa, T. Excitatory responses to scyliorhinins I and II in smooth muscle strips isolated from the carp intestinal bulb (Cyprinus carpio). Naunyn Schmiedebergs Arch Pharmacol. 343(5), 525-531 (1991).

    3. Raffa, R.B., Martinez, R.P., and Connelly, C.D. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: Differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci. Lett. 158(1), 87-91 (1993).