A fluorogenic substrate for β-glucocerebrosidase
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4-Methylumbelliferyl-hexadecyloxy-β-D-Glucopyranoside

Item No. 43067

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(((2S,3R,4S,5S,6R)-6-((hexadecyloxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-4-methyl-2H-chromen-2-one
Synonyms
  • 4-Methylumbelliferyl-hexadecyloxy-β-D-Glucoside
  • 4-MU-hexadecyloxy-β-D-Glucopyranoside
Molecular Formula
C32H50O8
Formula Weight
562.7
Purity
≥98%
Formulation (Request formulation change)
A 1 mg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
Acetonitrile: Sparingly soluble: 1-10 mg/mlChloroform: Sparingly soluble: 1-10 mg/ml
SMILES
O=C1C=C(C)C2=C(C=C(O[C@@H]3O[C@H](COCCCCCCCCCCCCCCCC)[C@@H](O)[C@H](O)[C@H]3O)C=C2)O1
InChi Code
InChI=1S/C32H50O8/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-19-37-22-27-29(34)30(35)31(36)32(40-27)38-24-17-18-25-23(2)20-28(33)39-26(25)21-24/h17-18,20-21,27,29-32,34-36H,3-16,19,22H2,1-2H3/t27-,29-,30+,31-,32-/m1/s1
InChi Key
HBRCCZFTZZIJEU-KBNMYVHASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $275

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    Product Description

    4-Methylumbelliferyl-hexadecyloxy-β-D-glucopyranoside is a fluorogenic substrate for β-glucocerebrosidase (GBA1).1 It is selective for GBA1 over GBA2 and GBA3. Hydrolysis of 4-methylumbelliferyl-hexadecyloxy-β-D-glucopyranoside by GBA1 releases the fluorescent moiety 4-MU, which displays an emission maximum between 445-454 nm and a pH-dependent excitation maximum of 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.1,2 4-Methylumbelliferyl-hexadecyloxy-β-D-glucopyranoside has been used to detect GBA1 activity in spleen lysates isolated from patients with Gaucher disease.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bannink, S., Bila, K.O., van Weperen, J., et al. 6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols. J. Lipid Res. 65(11), 100670 (2024).

    2. Zhi, H., Wang, J., Wang, S., et al. Fluorescent properties of hymecromone and fluorimetric analysis of hymecromone in compound dantong capsule. J. Spectrosc. 147128 (2013).