A PP5 inhibitor
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PP5-IN-1

Item No. 43071

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-dimethyl-N-[4-(phenylmethyl)phenyl]-4-isoxazolesulfonamide
CAS Number
1022417-69-1
Synonyms
  • P053
  • PP5-Inhibitor 1
  • Protein Phosphatase 5 Inhibitor 1
Molecular Formula
C18H18N2O3S
Formula Weight
342.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
O=S(C1=C(C)ON=C1C)(NC(C=C2)=CC=C2CC3=CC=CC=C3)=O
InChi Code
InChI=1S/C18H18N2O3S/c1-13-18(14(2)23-19-13)24(21,22)20-17-10-8-16(9-11-17)12-15-6-4-3-5-7-15/h3-11,20H,12H2,1-2H3
InChi Key
QDUOZMMIRWIMGB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    5 mg

    $72

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    10 mg

    $137

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    25 mg

    $323

    Add

    50 mg

    $609

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    Cayman Chemical
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    Product Description

    PP5-IN-1 is an inhibitor of protein phosphatase 5 (PP5; IC50 = 0.706 µM).1 It induces apoptosis in 786-O renal cell carcinoma (RCC) cells when used at a concentration of 10 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ahanin, E.F., Sager, R.A., Backe, S.J., et al. Catalytic inhibitor of Protein Phosphatase 5 activates the extrinsic apoptotic pathway by disrupting complex II in kidney cancer. Cell. Chem. Biol. 30(10), 1223-1234 (2023).