An active metabolite of nicotinamide
Related Products
Alternative(s)
166041-Methylnicotinamide (chloride)
Parent Compound(s)
11127Nicotinamide
Technical Support & Resources

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1-Methylnicotinamide (iodide)

Item No. 43076

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(aminocarbonyl)-1-methyl-pyridinium, monoiodide
CAS Number
6456-44-6
Synonyms
  • N1-Methylnicotinamide
  • 1-MNA
Molecular Formula
C7H9N2O • I
Formula Weight
264.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CC=C[N+](C)=C1)N.[I-]
InChi Code
InChI=1S/C7H8N2O.HI/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
InChi Key
IWEIZMCTGMHCRE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 mg

    $54

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    250 mg

    $95

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    500 mg

    $149

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    1 g

    $244

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    Product Description

    1-Methylnicotinamide is an active metabolite of nicotinamide (Item No. 11127).1 It is formed from nicotinamide by nicotinamide N-methyltransferase. 1-Methylnicotinamide induces nitric oxide secretion from human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner.2 It increases plasma levels of 6-keto-prostaglandin F1α (Item No. 15210) in rats when administered at a dose of 30 mg/kg and inhibits collagen-induced thrombus formation in rats at the same dose.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alston, T.A., and Abeles, R.H. Substrate specificity of nicotinamide methyltransferase isolated from porcine liver. Arch. Biochem. Biophys. 260(2), 601-608 (1988).

    2. Domagala, T.B., Szeffler, A., Dobrucki, L.W., et al. Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels. Hypertension 59(4), 825-832 (2012).

    3. Chlopicki, S., Swies, J., Mogielnicki, A., et al. 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway. Br. J. Pharmacol. 152(2), 230-239 (2007).