An NK1 and NK2 receptor peptide agonist
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Scyliorhinin I (dogfish) (trifluoroacetate salt)

Item No. 43081

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-alanyl-L-lysyl-L-phenylalanyl-L-α-aspartyl-L-lysyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl-L-methioninamide, trifluoroacetate salt
Synonyms
  • Ala-Lys-Phe-Asp-Lys-Phe-Tyr-Gly-Leu-Met-NH2
Molecular Formula
C59H87N13O13S • XCF3COOH
Formula Weight
1218.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
AKFDKFYGLM-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
OC(C=C1)=CC=C1C[C@@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](NC([C@@H](N)C)=O)CCCCN)=O)CC2=CC=CC=C2)=O)=O)=O)CC3=CC=CC=C3)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C59H87N13O13S.C2HF3O2/c1-35(2)29-44(56(82)66-41(51(63)77)25-28-86-4)65-49(74)34-64-53(79)45(32-39-21-23-40(73)24-22-39)69-57(83)46(30-37-15-7-5-8-16-37)71-55(81)43(20-12-14-27-61)68-59(85)48(33-50(75)76)72-58(84)47(31-38-17-9-6-10-18-38)70-54(80)42(19-11-13-26-60)67-52(78)36(3)62;3-2(4,5)1(6)7/h5-10,15-18,21-24,35-36,41-48,73H,11-14,19-20,25-34,60-62H2,1-4H3,(H2,63,77)(H,64,79)(H,65,74)(H,66,82)(H,67,78)(H,68,85)(H,69,83)(H,70,80)(H,71,81)(H,72,84)(H,75,76);(H,6,7)/t36-,41-,42-,43-,44-,45-,46-,47-,48-;/m0./s1
InChi Key
CZNVDLZRNPMQOJ-QCZWRTFKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $98

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    5 mg

    $318

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    10 mg

    $490

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    25 mg

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    Product Description

    Scyliorhinin I is a neurokinin-1 (NK1) and NK2 receptor peptide agonist that has been found in dogfish intestines.1,2 It binds to membrane preparations of rat submandibular gland and hamster urinary bladder (Kis = 0.9 and 2 nM, respectively), tissues that endogenously express high levels of NK1 and NK2 receptors, respectively. It increases intracellular levels of inositol-1,4,5-trisphosphate (IP3) in KNRK rat kidney cells expressing the NK1 receptor when used at a concentration of 1 µM.2 Scyliorhinin I induces contractions in isolated and perfused carp intestinal bulb smooth muscle strips (EC50 = 15 nM).3 Intrathecal or intracerebroventricular administration of scyliorhinin I induces reciprocal hindlimb neck-scratching behavior in mice (ED50s = 0.07 and 0.05 nmol/animal, respectively).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Buck, S.H., and Krstenansky, J.L. The dogfish peptides scyliorhinin I and scyliorhinin II bind with differential selectivity to mammalian tachykinin receptors. Eur. J. Pharmacol. 144(1), 109-111 (1987).

    2. Vigna, S.R. The role of the amino-terminal domain of tachykinins in neurokinin-1 receptor signaling and desensitization. Neuropeptides 37(1), 30-35 (2003).

    3. Kitazawa, T. Excitatory responses to scyliorhinins I and II in smooth muscle strips isolated from the carp intestinal bulb (Cyprinus carpio). Naunyn Schmiedebergs Arch Pharmacol. 343(5), 525-531 (1991).

    4. Raffa, R.B., Martinez, R.P., and Connelly, C.D. Scyliorhinin-I and -II induce reciprocal hindlimb scratching in mice: Differentiation of spinal and supraspinal neurokinin receptors in vivo. Neurosci. Lett. 158(1), 87-91 (1993).