CDU

CDU is an inhibitor of soluble epoxide hydrolase (sEH; IC₅₀s = 9.8 and 85.2 nM for the mouse and human enzymes, respectively).¹ It inhibits the proliferation of, and decreases the levels of cyclin D1 in, primary human vascular smooth muscle cells (VSMCs) when used at a concentration of 10 µM.² CDU (10 µM) induces relaxation in isolated rat precontracted mesenteric resistance vessels.³ It decreases tail cuff blood pressure and urinary excretion of 14(15)-dihydroxyeicosatrienoic acid in a rat model of angiotensin II infusion-induced hypertension.⁴

WARNING This product is not for human or veterinary use.

1. Davis, B.B., Thompson, D.A., Howard, L.L., et al. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc. Natl. Acad. Sci. USA 99(4), 2222-2227 (2002).

2. Olearczyk, J.J., Field, M.B., Kim, I.H., et al. Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. J. Pharmacol. Exp. Ther. 318(3), 1307-1314 (2006).

3. Imig, J.D., Zhoa, X., Capdevila, J.H., et al. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension 39, 690-694 (2002).