An anticancer agent
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SW106065

Item No. 43107

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-3-pyridinyl-2-thiophenecarboxamide
CAS Number
62289-81-0
Molecular Formula
C10H8N2OS
Formula Weight
204.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NC1=CC=CN=C1)C2=CC=CS2
InChi Code
InChI=1S/C10H8N2OS/c13-10(9-4-2-6-14-9)12-8-3-1-5-11-7-8/h1-7H,(H,12,13)
InChi Key
UPLHUDRMLWWFRE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    5 mg

    $72

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    10 mg

    $137

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    25 mg

    $304

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    50 mg

    $429

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    Cayman Chemical
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    Product Description

    SW106065 is an anticancer agent.1 It decreases the proliferation of S462 and SNF96.2 neurofibroma cells (EC50s = 439 and 753.6 nM). SW106065 (2.5 µM) induces apoptosis and cell cycle arrest at the G1/G0 and G2/M phases in primary patient-derived malignant peripheral nerve sheath tumor (MPNST) cells. In vivo, SW106065 (40 mg/kg twice per day) decreases tumor volume in a patient-derived xenograft (PDX) mouse model of MPNSTs. It also reduces influenza A H1N1 and H3N2 strain replication in MDCK cells (EC50s = 0.17 and 0.085 µM, respectively) with a 50% cytotoxicity concentration (CC50) value of 36 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chau, V., Lim, S.K., Mo, W., et al. Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Res. 74(2), 586-597 (2014).

    2. Vanderlinden, E., Marchand, A., Van Berwaer, R., et al. A broad influenza virus inhibitor acting via IMP dehydrogenase and in synergism with ribavirin. Antiviral Res. 196, 105208 (2021).