An FFAR1/GPR40 agonist
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LY2922470

Item No. 43109

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(βS)-4-[[5-[(3,4-dihydro-8-methoxy-1(2H)-quinolinyl)methyl]-2-thienyl]methoxy]-β-1-propyn-1-yl-benzenepropanoic acid
CAS Number
1423018-12-5
Molecular Formula
C28H29NO4S
Formula Weight
475.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
SMILES
OC(C[C@@H](C1=CC=C(C=C1)OCC2=CC=C(CN3CCCC4=CC=CC(OC)=C43)S2)C#CC)=O
InChi Code
InChI=1S/C28H29NO4S/c1-3-6-22(17-27(30)31)20-10-12-23(13-11-20)33-19-25-15-14-24(34-25)18-29-16-5-8-21-7-4-9-26(32-2)28(21)29/h4,7,9-15,22H,5,8,16-19H2,1-2H3,(H,30,31)/t22-/m0/s1
InChi Key
VJVDLRVFJTVWEO-QFIPXVFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $86

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    5 mg

    $323

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    10 mg

    $472

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    Product Description

    LY2922470 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40).1 It induces calcium flux in HEK293 cells expressing FFAR1/GPR40 (EC50s = 7, 1, and 3 nM for the human, mouse, and rat receptor, respectively). LY2922470 (30 mg/kg) increases blood levels of glucagon-like peptide 1 (GLP-1) in fasted mice. It also decreases cerebral infarct area in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO) when administered at doses of 10, 20, or 40 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hamdouchi, C., Kahl, S.D., Lewis, A.P., et al. The discovery, preclinical, and early clinical development of potent and selective GPR40 agonists for the treatment of type 2 diabetes mellitus (LY2881835, LY2922083, and LY2922470). J. Med. Chem. 59(24), 10891-10916 (2016).

    2. Lu, Y., Zhou, W., Cui, Q., et al. G protein-coupled receptor 40 agonist LY2922470 alleviates ischemic-stroke-induced acute brain injury and functional alterations in mice. Int. J. Mol. Sci. 24(15), 12244 (2023).