An inhibitor of USP9X, USP24, and USP5
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EOAI3402143

Item No. 43117

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2E-cyano-3-(3,6-dichloro-2-pyridinyl)-N-[1-[4-[2-(4-morpholinyl)ethoxy]phenyl]butyl]-2-propenamide
CAS Number
1699750-95-2
Synonyms
  • G9
Molecular Formula
C25H28Cl2N4O3
Formula Weight
503.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CCCC(C1=CC=C(C=C1)OCCN2CCOCC2)NC(/C(C#N)=C/C3=C(C=CC(Cl)=N3)Cl)=O
InChi Code
InChI=1S/C25H28Cl2N4O3/c1-2-3-22(30-25(32)19(17-28)16-23-21(26)8-9-24(27)29-23)18-4-6-20(7-5-18)34-15-12-31-10-13-33-14-11-31/h4-9,16,22H,2-3,10-15H2,1H3,(H,30,32)/b19-16+
InChi Key
IIKVQQNZHGBYGQ-KNTRCKAVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $204

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    10 mg

    $326

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    25 mg

    $611

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    50 mg

    $1,018

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    Cayman Chemical
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    Product Description

    EOAI3402143 is an inhibitor of ubiquitin-specific protease 9X (USP9X), USP24, and USP5.1 It inhibits the catalytic domain of USP9X (IC50 = 1.6 µM). EOAI3402143 (5 µM) inhibits USP9X, USP24, and USP5 in MM.1S multiple myeloma cells. It inhibits the growth of vemurafenib-sensitive and -resistant A375 melanoma cells (IC50s = 1 µM).2 In vivo, EOAI3402143 (15 mg/kg) reduces tumor volume in MM.1S and A375 mouse xenograft models.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peterson, L.F., Sun, H., Liu, Y., et al. Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies. Blood 125(23), 3588-3597 (2015).

    2. Potu, H., Peterson, L.F., Pal, A., et al. Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway. Oncotarget 5(14), 5559-5569 (2014).