An ionizable cationic lipid
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Lipid 20b

Item No. 43121

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5,6,7-tetrahydro-2-[[(9Z,12Z)-1-oxo-9,12-octadecadien-1-yl]amino]-thieno[2,3-c]pyridine-3-carboxylic acid, (9Z,12Z)-9,12-octadecadien-1-yl ester
CAS Number
2921586-65-2
Molecular Formula
C44H72N2O3S
Formula Weight
709.1
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥ 10 mg/ml
SMILES
CCCCC/C=C\C/C=C\CCCCCCCCOC(C1=C(NC(CCCCCCC/C=C\C/C=C\CCCCC)=O)SC2=C1CCNC2)=O
InChi Code
InChI=1S/C44H72N2O3S/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-37-49-44(48)42-39-35-36-45-38-40(39)50-43(42)46-41(47)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h11-14,17-20,45H,3-10,15-16,21-38H2,1-2H3,(H,46,47)/b13-11-,14-12-,19-17-,20-18-
InChi Key
IGCXVXZVYNWGQF-MAZCIEHSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $196

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    25 mg

    $464

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    50 mg

    $818

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    Cayman Chemical
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    Product Description

    Lipid 20b is a thiophene ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing lipid 20b and encapsulating mRNA encoding a luciferase reporter induce bioluminescence in the lungs, spleen, and retina of mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eygeris, Y., Gupta, M., Kim, J., et al. Thiophene-based lipids for mRNA delivery to pulmonary and retinal tissues. Proc. Natl. Acad. Sci. USA 121(11), e2307813120 (2024).