An inhibitor of the HECTD2-PIAS1 protein-protein interaction
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BC-1382

Item No. 43143

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-2-[[(2-methoxyphenyl)methyl]amino]-1-methyl-2-oxoethyl]-1-(phenylsulfonyl)-4-piperidinecarboxamide
CAS Number
1013753-99-5
Molecular Formula
C23H29N3O5S
Formula Weight
459.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=S(N1CCC(CC1)C(N[C@@H](C)C(NCC2=C(OC)C=CC=C2)=O)=O)(C3=CC=CC=C3)=O
InChi Code
InChI=1S/C23H29N3O5S/c1-17(22(27)24-16-19-8-6-7-11-21(19)31-2)25-23(28)18-12-14-26(15-13-18)32(29,30)20-9-4-3-5-10-20/h3-11,17-18H,12-16H2,1-2H3,(H,24,27)(H,25,28)/t17-/m0/s1
InChi Key
RCWXKFCEGKXUIN-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    5 mg

    $204

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    10 mg

    $388

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    50 mg

    $1,018

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    100 mg

    $1,832

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    Cayman Chemical
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    Product Description

    BC-1382 is an inhibitor of the protein-protein interaction between E3 ubiquitin-protein ligase HECTD2 and E3 SUMO-protein ligase PIAS1.1 It inhibits the HECTD2-PIAS1 protein-protein interaction (IC50 = ~5 nM in a pull-down assay) and increases the stability and levels of PIAS1. BC-1382 (10 mg/kg) decreases Tnf and Il-6 levels in bronchoalveolar lavage fluid (BALF) in mouse models of P. aeruginosa- or LPS-induced pneumonia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Coon, T.A., McKelvey, A.C., Lear, T., et al. The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Sci. Transl. Med. 7(295), 295ra109 (2015).