Hexestrol-d₆

Hexestrol-d₆ is intended for use as an internal standard for the quantification of hexestrol (Item No. 29003) by GC- or LC-MS. Hexestrol is a synthetic non-steroidal estrogen receptor ligand that binds to estrogen receptor α (ERα) and ERβ (K_is = 0.06 and 0.06 nM for the human and rat receptors, respectively).¹ It inhibits rat liver microsomal and ox brain phospholipid liposomal lipid peroxidation (IC₅₀s = 1.5 and 2.75 μM, respectively).² It also inhibits porcine microtubule assembly and induces disassembly of preformed microtubules when used at concentrations of 50 and 100 μM, respectively, in a cell-free assay.³ Hexestrol (25 mg/animal) induces kidney tumors in male Syrian hamsters.⁴

WARNING This product is not for human or veterinary use.

1. Kuiper, G.G.J.M., Carlsson, B., Grandien, K., et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β. Endocrinology 138(3), 863-870 (1997).

2. Wiseman, H., and Halliwell, B. Carcinogenic antioxidants. Diethylstilboestrol, hexoestrol and 17 α-ethynyloestradiol. FEBS Lett. 332(1-2), 159-163 (1993).

3. Sato, Y., Murai, T., Oda, T., et al. Inhibition of microtubule polymerization by synthetic estrogens: Formation of a ribbon structure. J. Biochem. 101(5), 1247-1252 (1987).

4. Liehr, J.G., Ballatore, A.M., Dague, B.B., et al. Carcinogenicity and metabolic activation of hexestrol. Chem. Biol. Interact. 55(1-2), 157-176 (1985).