A calmodulin antagonist
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Isomer(s)
14826W-7 (hydrochloride)
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W-9 (hydrochloride)

Item No. 43152

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(6-aminohexyl)-5-chloro-2-naphthalenesulfonamide, monohydrochloride
CAS Number
69762-85-2
Molecular Formula
C16H21ClN2O2S • HCl
Formula Weight
377.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly Soluble: 1-10 mg/mlEthanol: Slightly Soluble: 0.1-1 mg/ml
SMILES
O=S(NCCCCCCN)(C1=CC2=C(C(Cl)=CC=C2)C=C1)=O.Cl
InChi Code
InChI=1S/C16H21ClN2O2S.ClH/c17-16-7-5-6-13-12-14(8-9-15(13)16)22(20,21)19-11-4-2-1-3-10-18;/h5-9,12,19H,1-4,10-11,18H2;1H
InChi Key
FGWDLQXTCSKXSK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 mg

    $64

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    5 mg

    $128

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    10 mg

    $224

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    50 mg

    $479

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    Cayman Chemical
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    Product Description

    W-9 is a calmodulin antagonist (IC50 = 16 µM in a radioligand binding assay).1 It inhibits calmodulin-dependent phosphodiesterase (PDE) activation in a cell-free assay (IC50 = 14 µM) and erythrocyte ghost ATPase activation (IC50s = 15-18 µM).1,2 W-9 induces relaxation in isolated rabbit aortic strips precontracted with prostaglandin F2α (PGF2α; EC50 = 72 µM) and inhibits ATP-induced superprecipitation of bovine aorta smooth muscle actomyosin (IC50 = 46 µM).3 It also inhibits the replication of dengue virus in HEK293 cells (IC50 = 3.19 µM).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hidaka, H., and Tanaka, T. Naphthalenesulfonamides as calmodulin antagonists. Methods Enzymol. 102, 185-194 (1983).

    2. Kobayashi, R., Tawata, M., and Hidaka, H. Ca2+ regulated modulator protein interacting agents: inhibition of Ca2+-Mg2+-ATPase of human erythrocyte ghost. Biochem. Biophys. Res. Commun. 88(3), 1037-1045 (1979).

    3. Hidaka, H., Yamaki, T., Totsuka, T., et al. Selective inhibitors of Ca2+-binding modulator of phosphodiesterase produce vascular relaxation and inhibit actin-myosin interaction. Mol. Pharmacol. 15(1), 49-59 (1979).

    4. Shum, D., Smith, J.L., Hirsch, A.J., et al. High-content assay to identify inhibitors of dengue virus infection. Assay Drug Dev. Technol. 8(5), 553-570 (2010).