An ionizable cationic lipid
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Lipid PPz-2R1

Item No. 43160

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
piperazine-1,4-diylbis(hexane-6,1-diyl) bis(2-hexyldecanoate)
CAS Number
2832061-40-0
Molecular Formula
C48H94N2O4
Formula Weight
763.3
Purity
≥98%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Soluble: ≥10 mg/ml
SMILES
O=C(C(CCCCCC)CCCCCCCC)OCCCCCCN1CCN(CCCCCCOC(C(CCCCCCCC)CCCCCC)=O)CC1
InChi Code
InChI=1S/C48H94N2O4/c1-5-9-13-17-19-27-35-45(33-25-15-11-7-3)47(51)53-43-31-23-21-29-37-49-39-41-50(42-40-49)38-30-22-24-32-44-54-48(52)46(34-26-16-12-8-4)36-28-20-18-14-10-6-2/h45-46H,5-44H2,1-4H3
InChi Key
KGIUXRFGRZABFM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $76

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    5 mg

    $361

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    10 mg

    $684

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    25 mg

    $1,044

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    Cayman Chemical
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    Product Description

    Lipid PPz-2R1 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing lipid PPz-2R1 and encapsulating an mRNA reporter selectively accumulate in lungs over the heart, liver, spleen, and kidneys in mice. LNPs containing lipid PPz-2R1 and encapsulating mRNA encoding phosphatase and tensin homolog (PTEN) increase PTEN protein levels in PTEN-deficient Lewis lung carcinoma (LLC) cells. Lipid PPz-2R1-containing LNPs encapsulating PTEN mRNA reduce tumor growth in an orthotopic murine LLC model when administered alone or in combination with an antibody targeting programmed cell death protein 1 (PD-1).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, Y., He, X., Chen, P., et al. Lung-targeted delivery of PTEN mRNA combined with anti-PD-1-mediated immunotherapy for in situ lung cancer treatment. Acta Biomater. (2025).