An inhibitor of topoisomerase II and xanthine oxidoreductase
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Merbarone

Item No. 43165

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
hexahydro-4,6-dioxo-N-phenyl-2-thioxo-5-pyrimidinecarboxamide
CAS Number
97534-21-9
Synonyms
  • NSC 336628
  • RLBN 1001
Molecular Formula
C11H9N3O3S
Formula Weight
263.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1C(NC(NC1=O)=S)=O)NC2=CC=CC=C2
InChi Code
InChI=1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
InChi Key
JARCFMKMOFFIGZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $103

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    25 mg

    $175

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    Cayman Chemical
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    Product Description

    Merbarone is an inhibitor of topoisomerase II (IC50 = 20 µM) and xanthine oxidoreductase (IC50 = 51 µM).1,2 It is selective for topoisomerase II over topoisomerase I (IC50 = ~200 µM).1 Merbarone increases lifespan in a variety of murine cancer models, including B16 melanoma, L1210 leukemia, P388 leukemia, and M5076 sarcoma models.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Drake, F.H., Hofmann, G.A., Mong, S.M., et al. In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone. Cancer Res. 49(10), 2578-2583 (1989).

    2. Muindi, J.F., Stevens, Y.-W., Warrell, R.P., Jr., et al. In vitro differential metabolism of merbarone by xanthine oxidase and microsomal flavoenzymes. The role of reactive oxygen species. Drug Metab. Dispos. 21(3), 410-414 (1993).

    3. Glover, A., Chun, H.G., Kleinman, L.M., et al. Merbarone: An antitumor agent entering clinical trials. Invest. New Drugs 5(2), 137-143 (1987).