A NOP receptor agonist
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SCH 221510

Item No. 43181

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3-endo)-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
CAS Number
322473-89-2
Molecular Formula
C28H31NO
Formula Weight
397.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
O[C@](C[C@@]1([H])CC2)(C3=CC=CC=C3)C[C@@]2([H])N1C(C4=C(C=CC=C4)C)C5=C(C=CC=C5)C
InChi Code
InChI=1S/C28H31NO/c1-20-10-6-8-14-25(20)27(26-15-9-7-11-21(26)2)29-23-16-17-24(29)19-28(30,18-23)22-12-4-3-5-13-22/h3-15,23-24,27,30H,16-19H2,1-2H3/t23-,24+,28+
InChi Key
LOSJNRBXNQTUNT-FOURXJPJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $215

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    10 mg

    $323

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    25 mg

    $752

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    50 mg

    $1,181

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    Product Description

    SCH 221510 is an agonist of nociceptin opioid peptide (NOP) receptor.1 It induces [35S]GTPγS binding to CHO membranes expressing recombinant human NOP receptors (EC50 = 12 nM). SCH 221510 (10 mg/kg) increases time spent in the open arms and number of open arm entries in an elevated plus maze in rats. It increases drinking in the Vogel punished drinking task in rats when administered at doses of 3, 10, or 30 mg/kg. SCH 221510 (0.3, 1, or 3 mg/kg) reduces the number of vocalizations in a guinea pig pup model of separation-induced anxiety. It decreases the number of coughs in a guinea pig model of capsaicin-induced coughing (ED50 = 0.07 mg/kg).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Varty, G.B., Lu, S.X., Morgan, C.A., et al. The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510). J. Pharmacol. Exp. Ther. 326(2), 672-682 (2008).

    2. Ho, G.D., Anthes, J., Bercovici, A., et al. The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety. Bioorg. Med. Chem. Lett. 19(9), 2519-2523 (2009).