A derivative of 3-phenylglutaric acid
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84-B10

Item No. 43187

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
β-[2-[[2-(4-methoxyphenoxy)-5-(trifluoromethyl)phenyl]amino]-2-oxoethyl]-benzenepropanoic acid
CAS Number
698346-43-9
Molecular Formula
C25H22F3NO5
Formula Weight
473.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(CC(CC(NC1=CC(C(F)(F)F)=CC=C1OC2=CC=C(C=C2)OC)=O)C3=CC=CC=C3)O
InChi Code
InChI=1S/C25H22F3NO5/c1-33-19-8-10-20(11-9-19)34-22-12-7-18(25(26,27)28)15-21(22)29-23(30)13-17(14-24(31)32)16-5-3-2-4-6-16/h2-12,15,17H,13-14H2,1H3,(H,29,30)(H,31,32)
InChi Key
UMUXAMJXLBOQNN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $31

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    5 mg

    $139

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    10 mg

    $247

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    25 mg

    $539

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    Product Description

    84-B10 is a derivative of 3-phenylglutaric acid.1 It restores mitochondrial architecture and increases spare respiratory capacity in TKPTS renal tubular epithelial cells when used at concentrations ranging from 10 to 100 µM. 84-B10 (10-100 µM) inhibits lipid peroxidation and ferroptosis induced by cisplatin (Item No. 13119) in the same cells. In vivo, 84-B10 (5, 10, and 15 mg/kg) reduces renal tubular injury and blood urea nitrogen (BUN) levels in a mouse model of cisplatin-induced acute kidney injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fan, J., Xu, X., Li, Y., et al. A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial oxidative stress-mediated ferroptosis. Free. Radic. Biol. Med. 194, 84-98 (2023).