An antagonist of NR1A/2B subunit-containing NMDA receptors
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Co 101244 (hydrochloride)

Item No. 43192

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinol, monohydrochloride
CAS Number
193356-17-1
Synonyms
  • PD 174494
Molecular Formula
C21H27NO3 • HCl
Formula Weight
377.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
OC1=CC=C(C=C1)OCCN2CCC(O)(CC2)CC3=CC=C(C)C=C3.Cl
InChi Code
InChI=1S/C21H27NO3.ClH/c1-17-2-4-18(5-3-17)16-21(24)10-12-22(13-11-21)14-15-25-20-8-6-19(23)7-9-20;/h2-9,23-24H,10-16H2,1H3;1H
InChi Key
WFFZHKKSIDENAJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $105

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    10 mg

    $168

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    25 mg

    $392

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    50 mg

    $680

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    Product Description

    Co 101244 is an antagonist of NR1A/2B subunit-containing NMDA receptors (IC50 = 0.043 µM).1 It is selective for NR1A/2B subunit-containing NMDA receptors over NR1A/2A and NR1A/2C subunit-containing NMDA receptors (IC50s = >100 µM for both). In vivo, Co 101244 reduces the number of seizures induced by maximum electroshock (MES) in mice (ED50 = 1.5 mg/kg).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, Z.L., Cai, S.X., Whittemore, E.R., et al. 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: A novel, potent, and selective NR1/2B NMDA receptor antagonist. J. Med. Chem. 42(15), 2993-3000 (1999).