An agonist of α4β2 and α6β2 subunit-containing nAChRs
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5-iodo A-85380 (hydrochloride)

Item No. 43194

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(2S)-2-azetidinylmethoxy]-5-iodo-pyridine, dihydrochloride
CAS Number
1217837-17-6
Molecular Formula
C9H11IN2O • 2HCl
Formula Weight
363.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Soluble: ≥ 10 mg/ml
SMILES
IC1=CC(OC[C@@H]2CCN2)=CN=C1.Cl.Cl
InChi Code
InChI=1S/C9H11IN2O.2ClH/c10-7-3-9(5-11-4-7)13-6-8-1-2-12-8;;/h3-5,8,12H,1-2,6H2;2*1H/t8-;;/m0../s1
InChi Key
ZJVVFYWEBSHGBV-JZGIKJSDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $83

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    10 mg

    $149

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    25 mg

    $290

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    Product Description

    5-iodo A-85380 is an agonist of α4β2 and α6β2 subunit-containing nicotinic acetylcholine receptors (nAChRs).1 It activates α-conotoxin MII-sensitive and -insensitive dopamine release in rat striatal synaptosomes, markers of α4β2 and α6β2 subunit-containing nAChR activation, respectively (EC50s = 12.7 and ~35 nM, respectively). In vivo, 5-iodo A-85380 (0.37 µmol/kg per day) decreases the total number of abnormal involuntary movements (AIMs) in a rat model of L-DOPA-induced Parkinson’s disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mogg, A.J., Jones, F.A., Pullar, I.A., et al. Functional responses and subunit composition of presynaptic nicotinic receptor subtypes explored using the novel agonist 5-iodo-A-85380. Neuropharmacology 47(6), 848-859 (2004).

    2. Huang, L.Z., Campos, C., Ly, J., et al. Nicotinic receptor agonists decrease L-dopa-induced dyskinesias most effectively in partially lesioned parkinsonian rats. Neuropharmacology 60(6), 861-861 (2011).