A GPX4 ligand
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

GPX4 Activator 2

Item No. 43195

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,4-dimethoxyphenyl)-1-[5-(4-methyl-1-piperazinyl)-1,3,4-thiadiazol-2-yl]-1H-pyrrole-2-methanamine
CAS Number
950365-31-8
Molecular Formula
C20H26N6O2S
Formula Weight
414.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Sparingly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 0.1-1 mg/ml
SMILES
COC(C=C1OC)=CC=C1NCC2=CC=CN2C3=NN=C(N4CCN(C)CC4)S3
InChi Code
InChI=1S/C20H26N6O2S/c1-24-9-11-25(12-10-24)19-22-23-20(29-19)26-8-4-5-15(26)14-21-17-7-6-16(27-2)13-18(17)28-3/h4-8,13,21H,9-12,14H2,1-3H3
InChi Key
WOSPZXZOWHOQTI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $50

    Add

    5 mg

    $198

    Add

    10 mg

    $323

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    GPX4 activator 2 is a ligand for glutathione peroxidase 4 (GPX4; Kd = 0.426 µM).1 It inhibits erastin-induced ferroptosis in HT-1080 fibrosarcoma cells (EC50 = 7.8 µM). GPX4 activator 2 (10 µM) prevents erastin-induced increases in lipid peroxide levels in HT-1080 cells. In vivo, GPX4 activator 2 (25 mg/kg) decreases serum and cardiac levels of malondialdehyde (MDA) and cardiac levels of aspartate aminotransferase (Ast) and reduces myocardial cell degeneration in a mouse model of doxorubicin-induced myocardial injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, X., Guo, Y., Huang, Y., et al. GPX4 allosteric activators inhibit ferroptosis and exert myocardial protection in doxorubicin-induced myocardial injury mouse model. Eur. J. Med. Chem. 277, 116721 (2024).