An Epac2 inhibitor
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ESI-08

Item No. 43208

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-cyclohexyl-2-[[(2,5-dimethylphenyl)methyl]thio]-1,6-dihydro-6-oxo-5-pyrimidinecarbonitrile
CAS Number
301177-43-5
Molecular Formula
C20H23N3OS
Formula Weight
353.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/mLWater: Slightly Soluble: 0.1-1 mg/mL
SMILES
CC1=CC=C(C)C=C1CSC(NC(C2CCCCC2)=C3C#N)=NC3=O
InChi Code
InChI=1S/C20H23N3OS/c1-13-8-9-14(2)16(10-13)12-25-20-22-18(15-6-4-3-5-7-15)17(11-21)19(24)23-20/h8-10,15H,3-7,12H2,1-2H3,(H,22,23,24)
InChi Key
LSHOSZQLVLPEGG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $152

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    10 mg

    $289

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    25 mg

    $608

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    50 mg

    $911

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    Product Description

    ESI-08 is an inhibitor of exchange protein activated by cAMP 2 (Epac2; IC50 = 8.4 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, H., Tsalkova, T., Mei, F.C., et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg. Med. Chem. Lett. 22(12), 4038-4043 (2012).