Active • Host: • AA: 1-198 (full length) • Tag: N-terminal His • MW: 24 kDa
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Peroxiredoxin-2 (human, recombinant)

Item No. 43210

Product Insert (PDF)
Technical Information
Synonyms
  • Calpromotin
  • Natural Killer Cell-enhancing Factor B Trx Peroxidase 1
  • NKEFB
  • NKEF-B
  • Peroxiredoxin II
  • PRDX2
  • PRXII
  • Prx2
  • TDPx1
  • Thioredoxin Peroxidase 1
  • Thioredoxin-dependent Peroxide Reductase 1
  • TPx1
  • Trx Peroxidase 1
Purity
≥92% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/g of the protein as determined by the LAL method
Source
Active recombinant human N-terminal His-tagged Prx2 expressed in insect cells
Amino Acids
1-198 (full length)
MW
24 kDa
Formulation (Request formulation change)
Lyophilized from sterile 25 mM Tris, 100 mM sodium chloride, 10% glycerol, 0.5 mM TCEP, 0.02% tween-20, pH 7.5, 5% trehalose, 5% mannitol, and 0.01% tween-80
UniProt Accession №
P32119
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    100 µg

    $383

    Add
    Cayman Chemical
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    Product Description

    Peroxiredoxin-2 (Prx2) is a typical 2-Cys-containing Prx that is involved in the maintenance of cellular thiol redox homeostasis.1 It exists as a homodimer and is composed of a thioredoxin fold-containing catalytic domain, which contains peroxidatic and resolving cysteines (Cp and Cr, respectively), and a C-terminal arm.2 Prx2 is ubiquitously expressed and localizes to the cytosol, nucleus, mitochondria, and peroxisomes.3,1 During the catalytic cycle, hydrogen peroxide oxidizes Cp to form a sulfenic acid intermediate (C-SOH), which reacts with the Cr of the opposite subunit to form a disulfide bond that is subsequently restored to a reduced state by thioredoxin (Trx) or other thiols.1,2 Prx2 primarily acts on hydrogen peroxide but also reduces other peroxides, including lipid hydroperoxides, protein peroxides, peroxynitrite, and peroxymonocarbonate and plays an important role in resolution of oxidized hemoglobin and erythrocyte membranes.2 Cerebrospinal fluid levels of Prx2 are increased in patients with subarachnoid hemorrhage, and substantia nigra levels of Prx2 are increased in patients with Parkinson’s disease.1 Prx2 acts as a tumor-suppressor or -promotor in a context-dependent manner in various cancers. Cayman’s Peroxiredoxin-2 (human, recombinant) protein can be used for enzyme activity assays. This protein consists of 217 amino acids and has a calculated molecular weight of 24 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 27 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balasubramanian, P., Vijayarangam, V., Deviparasakthi, M.K.G., et al. Implications and progression of peroxiredoxin 2 (PRDX2) in various human diseases. Pathol. Res. Pract. 254, 155080 (2024).

    2. Sadowska-Bartosz, I., and Bartosz, G. Peroxiredoxin 2: An important element of the antioxidant defense of the erythrocyte. Antioxidants (Basel) 12(5), 1012 (2023).

    3. Dammeyer, P., and Arnér, E.S. Human Protein Atlas of redox systems - What can be learnt? Biochim. Biophys. Acta 1810(1), 111-138 (2011).