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Gabapentin lactam

Item No. 43246

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-azaspiro[4.5]decan-3-one
CAS Number
64744-50-9
Molecular Formula
C9H15NO
Formula Weight
153.2
Purity
≥98%
Formulation
A neat solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C1NCC2(CCCCC2)C1
InChi Code
InChI=1S/C9H15NO/c11-8-6-9(7-10-8)4-2-1-3-5-9/h1-7H2,(H,10,11)
InChi Key
JAWPQJDOQPSNIQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

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    25 mg

    $97

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    Product Description

    Gabapentin lactam (Item No. 43246) is an analytical reference standard categorized as a degradation product of gabapentin.1,2 Gabapentin lactam is a potential impurity in gabapentin preparations.1 It has convulsant activity in rats.3 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ciavarella, A.B., Gupta, A., Sayeed, V.A., et al. Development and application of a validated HPLC method for the determination of gabapentin and its major degradation impurity in drug products. J. Pharm. Biomed. Anal. 43(5), 1647-1653 (2007).

    2. He, Y., Jia, D., Du, S., et al. Toxicity of gabapentin-lactam on the early developmental stage of zebrafish (Danio rerio). Environ. Pollut. 287, 117649 (2021).

    3. Potschka, H., Feuerstein, T.J., and Löscher, W. Gabapentin-lactam, a close analogue of the anticonvulsant gabapentin, exerts convulsant activity in amygdala kindled rats. Naunyn Schmiedebergs Arch. Pharmacol. 361(2), 200-205 (2000).