A K2P2.1/TREK-1 and K2P10.1/TREK-2 activator
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ONO-2920632

Item No. 43257

Product Insert (PDF)
Technical Information
Formal Name
N-[[2-fluoro-4-(trifluoromethoxy)phenyl]methyl]-[1,2,4]triazolo[1,5-a]pyridine-6-carboxamide
CAS Number
2230296-66-7
Synonyms
  • VU6011887
Molecular Formula
C15H10F4N4O2
Formula Weight
354.3
Purity
≥98%
Formulation (Request formulation change)
A neat solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CN2N=CN=C2C=C1)NCC3=C(F)C=C(C=C3)OC(F)(F)F
InChi Code
InChI=1S/C15H10F4N4O2/c16-12-5-11(25-15(17,18)19)3-1-9(12)6-20-14(24)10-2-4-13-21-8-22-23(13)7-10/h1-5,7-8H,6H2,(H,20,24)
InChi Key
KDTQFQYXTWVBCC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $28

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    10 mg

    $42

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    50 mg

    $193

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    100 mg

    $358

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    Product Description

    ONO-2920632 is an activator of two-pore domain potassium channel 2.1 (K2P2.1/TREK-1) and K2P10.1/TREK-2.1 It induces K2P2.1/TREK-1 and K2P10.1/TREK-2 activity in thallium flux assays using CHO cells expressing K2P2.1/TREK-1 and HEK293 cells expressing K2P10.1/TREK-2 (EC50s = 2.8 and 0.3 µM, respectively). ONO-2920632 is selective for K2P2.1/TREK-1 and K2P10.1/TREK-2 over 72 other ion channels, G protein-coupled receptors (GPCRs), transporters, and nuclear hormones at 10 µM. In vivo, ONO-2920632 (3 mg/kg) prevents acetic acid-induced writhing in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yashiro, K., Iwaki, Y., Urata, H., et al. Discovery of ONO-2920632 (VU6011887): A highly selective and CNS penetrant TREK-2 (TWIK-related K+ channel 2) preferring activator in vivo tool compound. ACS Chem. Neurosci. 16(5), 960-967 (2025).