A K2P2.1/TREK-1 and K2P10.1/TREK-2 activator
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

ONO-2920632

Item No. 43257

Product Insert (PDF)
Technical Information
Formal Name
N-[[2-fluoro-4-(trifluoromethoxy)phenyl]methyl]-[1,2,4]triazolo[1,5-a]pyridine-6-carboxamide
CAS Number
2230296-66-7
Synonyms
  • VU6011887
Molecular Formula
C15H10F4N4O2
Formula Weight
354.3
Purity
≥98%
Formulation
A neat solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CN2N=CN=C2C=C1)NCC3=C(F)C=C(C=C3)OC(F)(F)F
InChi Code
InChI=1S/C15H10F4N4O2/c16-12-5-11(25-15(17,18)19)3-1-9(12)6-20-14(24)10-2-4-13-21-8-22-23(13)7-10/h1-5,7-8H,6H2,(H,20,24)
InChi Key
KDTQFQYXTWVBCC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $28

    Add

    10 mg

    $42

    Add

    50 mg

    $193

    Add

    100 mg

    $358

    Add
    Product Description

    ONO-2920632 is an activator of two-pore domain potassium channel 2.1 (K2P2.1/TREK-1) and K2P10.1/TREK-2.1 It induces K2P2.1/TREK-1 and K2P10.1/TREK-2 activity in thallium flux assays using CHO cells expressing K2P2.1/TREK-1 and HEK293 cells expressing K2P10.1/TREK-2 (EC50s = 2.8 and 0.3 µM, respectively). ONO-2920632 is selective for K2P2.1/TREK-1 and K2P10.1/TREK-2 over 72 other ion channels, G protein-coupled receptors (GPCRs), transporters, and nuclear hormones at 10 µM. In vivo, ONO-2920632 (3 mg/kg) prevents acetic acid-induced writhing in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yashiro, K., Iwaki, Y., Urata, H., et al. Discovery of ONO-2920632 (VU6011887): A highly selective and CNS penetrant TREK-2 (TWIK-related K+ channel 2) preferring activator in vivo tool compound. ACS Chem. Neurosci. 16(5), 960-967 (2025).