A precursor in the biosynthesis of mycophenolic acid
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5,7-Dihydroxy-4-methylphthalide

Item No. 43303

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5,7-dihydroxy-4-methyl-1(3H)-isobenzofuranone
CAS Number
27979-57-3
Synonyms
  • DHMP
Molecular Formula
C9H8O4
Formula Weight
180.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C1OCC2=C(C)C(O)=CC(O)=C21
InChi Code
InChI=1S/C9H8O4/c1-4-5-3-13-9(12)8(5)7(11)2-6(4)10/h2,10-11H,3H2,1H3
InChi Key
GXYQICKPCCBIIX-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $82

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    25 mg

    $136

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    Cayman Chemical
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    Product Description

    5,7-Dihydroxy-4-methylphthalide is a precursor in the biosynthesis of mycophenolic acid (Item No. 21716) in fungi.1 It is active against C. neoformans (IC50 = 18.08 µg/ml).2 5,7-Dihydroxy-4-methylphthalide inhibits LPS- or concanavalin A-induced proliferation of mouse splenic lymphocytes (IC50s = 3 and 17 µM, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hansen, B.G., Mnich, E., Nielsen, K.F., et al. Involvement of a natural fusion of a cytochrome P450 and a hydrolase in mycophenolic acid biosynthesis. Appl. Environ. Microb. 78(14), 4908-4913 (2012).

    2. Gao, J., Radwan, M.M., León, F., et al. Antimicrobial and antiprotozoal activities of secondary metabolites from the fungus Eurotium repens. Med. Chem. Res. 21(10), 3080-3086 (2012).

    3. Fujimoto, H., Fujimaki, T., Okuyama, E., et al. Immunomodulatory constituents from an ascomycete, Microascus tardifaciens. Chem. Pharm. Bull. (Tokyo) 47(10), 1426-1432 (1999).