An RBPJ inhibitor
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RBPJ Inhibitor-1

Item No. 43358

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-fluorophenoxy)-4-(1-methyl-1H-pyrazol-5-yl)-benzamide
CAS Number
2682114-39-0
Synonyms
  • RIN1
Molecular Formula
C17H14FN3O2
Formula Weight
311.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C(N)C1=C(C=C(C2=CC=NN2C)C=C1)OC3=C(C=CC=C3)F
InChi Code
InChI=1S/C17H14FN3O2/c1-21-14(8-9-20-21)11-6-7-12(17(19)22)16(10-11)23-15-5-3-2-4-13(15)18/h2-10H,1H3,(H2,19,22)
InChi Key
MFSSHRCJKRDIOL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $108

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    10 mg

    $184

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    25 mg

    $297

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    50 mg

    $539

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    Product Description

    RBPJ inhibitor-1 is an inhibitor of recombination signal binding protein for immunoglobulin kappa J region (RBPJ; IC50 = 0.18 µM in a reporter assay).1 It also inhibits the protein-protein interaction between RBPJ and the neurogenic locus notch homolog protein 2 (Notch2) intracellular domain (NICD) and the protein-protein interaction between RBPJ and small histidine-alanine-rich protein (SHARP) in cell-free assays. RBPJ inhibitor-1 (15 µM) induces cell cycle arrest at the G2/M phase and apoptosis in UT-SCC-42B squamous cell carcinoma cells.2 It reduces tumor volume in D. rerio larvae injected with UT-SCC-42B cells when administered in the tank water at a concentration of 5 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hurtado, C., Safarova, A., Smith, M., et al. Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ. Sci. Rep. 9(1), 10811 (2019).

    2. Czerwonka, A., Kałafut, J., Wang, S., et al. Evaluation of the anticancer activity of RIN-1, a Notch signaling modulator, in head and neck squamous cell carcinoma. Sci. Rep. 13(1), 13700 (2023).