A Bcl-xL inhibitor
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A-385358

Item No. 43417

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-4-(4,4-dimethyl-1-piperidinyl)-benzamide
CAS Number
406228-55-5
Molecular Formula
C32H41N5O5S2
Formula Weight
639.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble: ≥ 10 mg/mlDMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C(C1=CC=C(N2CCC(C)(CC2)C)C=C1)NS(C3=CC=C(C([N+]([O-])=O)=C3)N[C@@H](CSC4=CC=CC=C4)CCN(C)C)(=O)=O
InChi Code
InChI=1S/C32H41N5O5S2/c1-32(2)17-20-36(21-18-32)26-12-10-24(11-13-26)31(38)34-44(41,42)28-14-15-29(30(22-28)37(39)40)33-25(16-19-35(3)4)23-43-27-8-6-5-7-9-27/h5-15,22,25,33H,16-21,23H2,1-4H3,(H,34,38)/t25-/m1/s1
InChi Key
DWEHITNKTMMZBR-RUZDIDTESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $229

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    10 mg

    $351

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    25 mg

    $675

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    Cayman Chemical
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    Product Description

    A-385358 is an inhibitor of Bcl-xL (Ki = 0.8 nM).1 It is selective for Bcl-xL over Bcl-2 (Ki = 67 nM). A-385358 decreases the proliferation of NCI H146 small cell lung carcinoma, MOLT-4 T lymphoblast, and CCRF CEM lymphoblastic leukemia cells in serum-free media (IC50s = 0.35, 0.74, and 0.21 µM, respectively). In vivo, A-385358 (100 mg/kg per day) in combination with paclitaxel (Item No. 10461) reduces tumor growth in an A549 lung cancer mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shoemaker, A.R., Oleksijew, A., Bauch, J., et al. A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo. Cancer Res. 66(17), 8731-8739 (2006).