An MCD inhibitor
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CBM 301940

Item No. 43420

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[[4,5-dihydro-5-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]-3-isoxazolyl]carbonyl]amino]-butanoic acid, 1,1-dimethylethyl ester
CAS Number
902146-11-6
Molecular Formula
C15H20F6N2O5
Formula Weight
422.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Soluble: ≥10 mg/ml
SMILES
CC(C)(OC(CC(NC(C1=NOC(C(C(F)(F)F)(O)C(F)(F)F)C1)=O)C)=O)C
InChi Code
InChI=1S/C15H20F6N2O5/c1-7(5-10(24)27-12(2,3)4)22-11(25)8-6-9(28-23-8)13(26,14(16,17)18)15(19,20)21/h7,9,26H,5-6H2,1-4H3,(H,22,25)
InChi Key
SBPVPWWNQIKSKL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $61

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    5 mg

    $152

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    10 mg

    $242

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    Product Description

    CBM 301940 is an inhibitor of malonyl-CoA decarboxylase (MCD; IC50 = 23 nM).1 It increases the rate of glucose oxidation in isolated and perfused rat hearts when used at a concentration of 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, J.F., Huang, Y., Penuliar, R., et al. Discovery of potent and orally available malonyl-CoA decarboxylase inhibitors as cardioprotective agents. J. Med. Chem. 49(14), 4055-4058 (2006).