A non-nucleoside reverse transcriptase inhibitor
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Trovirdine

Item No. 43467

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-bromo-2-pyridinyl)-N′-[2-(2-pyridinyl)ethyl]-thiourea
CAS Number
149488-17-5
Synonyms
  • LY300046
  • LY297345
Molecular Formula
C13H13BrN4S
Formula Weight
337.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
BrC(C=C1)=CN=C1NC(NCCC2=NC=CC=C2)=S
InChi Code
InChI=1S/C13H13BrN4S/c14-10-4-5-12(17-9-10)18-13(19)16-8-6-11-3-1-2-7-15-11/h1-5,7,9H,6,8H2,(H2,16,17,18,19)
InChi Key
HOCFDYZWQYGULA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $76

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    10 mg

    $137

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    25 mg

    $285

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    50 mg

    $494

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    Cayman Chemical
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    Product Description

    Trovirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).1 It inhibits HIV-1 wild-type reverse transcriptase (RT; IC50 = 0.017 µM) and the mutants RTL100I, RTE138R, RTY181C, RTY188H (IC50s = 0.43, 0.22, 2.5, and 0.2 µM, respectively). Trovirdine (5 mg/kg) delays p27 antigenemia and the appearance of anti-simian immunodeficiency virus (anti-SIV) antibodies in rhesus monkeys infected with transgenic SIV expressing HIV-1 RT.2 It is also active against T. gondii (IC50 = 18.89 µM).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, H., Vrang, L., Bäckbro, K., et al. Inhibition of human immunodeficiency virus type 1 wild-type and mutant reverse transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and MSC-127. Antiviral Res. 28(4), 331-342 (1995).

    2. Uberla, K., Stahl-Hennig, C., Böttiger, D., et al. Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors. Proc. Natl. Acad. Sci. USA 92(18), 8210-8214 (1995).

    3. Wang, J.-L., Elsheikha, H.M., Li, T.-T., et al. Efficacy of antiretroviral compounds against Toxoplasma gondii in vitro. Int. J. Antimicrob. Agents 54(6), 814-819 (2019).