An LSD1 inhibitor
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SP-2577

Item No. 43468

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(4-methyl-1-piperazinyl)sulfonyl]-benzoic acid, (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide
CAS Number
1423715-37-0
Synonyms
  • Seclidemstat
Molecular Formula
C20H23ClN4O4S
Formula Weight
450.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=S(C1=CC(C(N/N=C(C2=C(O)C=CC(Cl)=C2)\C)=O)=CC=C1)(N3CCN(CC3)C)=O
InChi Code
InChI=1S/C20H23ClN4O4S/c1-14(18-13-16(21)6-7-19(18)26)22-23-20(27)15-4-3-5-17(12-15)30(28,29)25-10-8-24(2)9-11-25/h3-7,12-13,26H,8-11H2,1-2H3,(H,23,27)/b22-14+
InChi Key
MVSQDUZRRVBYLA-HYARGMPZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $53

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    10 mg

    $85

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    50 mg

    $264

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    100 mg

    $476

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    Cayman Chemical
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    Product Description

    SP-2577 is an inhibitor of lysine-specific demethylase 1 (LSD1; IC50 = 13 nM).1 It induces cell death in a panel of 12 ovarian cancer cell lines expressing mutant switch/sucrose nonfermentable (SWI/SNF; IC50s = 0.013-2.819 µM). SP-2577 increases secretion of IFN-γ, IFN-β, IL-1β, IL-2, and IL-6 in COV434 ovarian cancer cells. It decreases the viability of primary natural killer T (NKT) cells and T cells and reduces the mitochondrial oxygen consumption rate (OCR) in NKT cells when used at a concentration of 5 µM.2 SP-2577 (5 µM) induces differentiation of primary rat neural stem cells into astrocytes.3 It increases infiltration of human peripheral blood mononuclear cells (PBMCs) into isolated COV434 tumor organoids in a migration and invasion assay when used at a concentration of 3 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Soldi, R., Halder, T.G., Weston, A., et al. The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer. PLoS One 15(7), e0235705 (2020).

    2. Bailey, C.P., Figueroa, M., Gangadharan, A., et al. Scaffolding LSD1 inhibitors impair NK cell metabolism and cytotoxic function through depletion of glutathione. Front. Immunol. 11, 2196 (2020).

    3. Kim, S., and Kim, H.-J. Histone lysine demethylase 1A inhibitors, seclidemstat and tranylcypromine, induce astrocytogenesis in rat neural stem cells. Biochem. Biophys. Res. Commun. 750, 151330 (2025).