An inhibitor of HDAC1 and HDAC2
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ACY-957 (hydrochloride)

Item No. 43477

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide, monohydrochloride
Molecular Formula
C24H23N5OS • HCl
Formula Weight
466.0
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
NC1=C(NC(C2=CC(C=C3)=C(C=C2)N=C3N4CCNCC4)=O)C=C(C5=CC=CS5)C=C1.Cl
InChi Code
InChI=1S/C24H23N5OS.ClH/c25-19-6-3-17(22-2-1-13-31-22)15-21(19)28-24(30)18-4-7-20-16(14-18)5-8-23(27-20)29-11-9-26-10-12-29;/h1-8,13-15,26H,9-12,25H2,(H,28,30);1H
InChi Key
AACRPMFRIVUUMC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $138

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    10 mg

    $262

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    25 mg

    $620

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    Product Description

    ACY-957 is an inhibitor of histone deacetylase 1 (HDAC1) and HDAC2 (IC50s = 7 and 18 nM, respectively).1 It is selective for HDAC1 and HDAC2 over HDAC3 (IC50 = 1,300 nM) and does not inhibit HDAC4-9 at concentrations up to 20 µM. ACY-957 (1 µM) induces expression of HBG, the gene encoding γ-globin, in peripheral blood mononuclear cells (PBMCs) isolated from patients with sickle cell disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shearstone, J.R., Golonzhka, O., Chonkar, A., et al. Chemical inhibition of histone deacetylases 1 and 2 induces fetal hemoglobin through activation of GATA2. PLoS One 11(4), e0153767 (2016).