An internal standard for the quantification of acotiamide
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Unlabeled Version(s)
43731Acotiamide (hydrochloride)
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Acotiamide-d6 (hydrochloride)

Item No. 43489

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-bis(methoxy-d3)benzamido)thiazole-4-carboxamide, monohydrochloride
Molecular Formula
C21H24D6N4O5S • HCl
Formula Weight
493.0
Purity
≥99% deuterated forms (d1-d6)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(C1=CSC(NC(C2=C(O)C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C2)=O)=N1)NCCN(C(C)C)C(C)C.Cl
InChi Code
InChI=1S/C21H30N4O5S.ClH/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26;/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27);1H/i5D3,6D3;
InChi Key
VQEKQYLTAIVCBW-PKKCSIJHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $468

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    Product Description

    Acotiamide-d6 is intended for use as an internal standard for the quantification of acotiamide by GC- or LC-MS. Acotiamide is an inhibitor of acetylcholinesterase (AChE; IC50 = 0.384 µM). It potentiates ACh-induced contraction of isolated guinea pig gastric and antrum strips when used at a concentration of 3 µM.1 Formulations containing acotiamide have been used in the treatment of functional dyspepsia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, K., Kawachi, M., Matsunaga, Y., et al. Acotiamide hydrochloride, a therapeutic agent for functional dyspepsia, enhances acetylcholine-induced contraction via inhibition of acetylcholinesterase activity in circular muscle strips of guinea pig stomach. Drug Res. (Stuttg.) 66(4), 196-202 (2016).