An Analytical Reference Standard
Features
  • This product has been formulated as an exempt preparation which meets criteria established by the US DEA
  • Possession of a DEA Controlled Substance registration is not necessary nor is a DEA 222 form required to purchase this product
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for academic research at qualified institutions; please contact our sales department for pricing
Related Products
Non-Exempt Preparation(s)
16930Allopregnanolone
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Allopregnanolone (exempt preparation)

Item No. 43516

Exempt Product (US)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • ALLO
  • Brexanolone
  • 3α,5α-tetrahydro Progesterone
  • 3α,5α-THP
Technical Information
Formal Name
(3α,5α)-3-hydroxy-pregnan-20-one
CAS Number
516-54-1
Molecular Formula
C21H34O2
Formula Weight
318.5
Purity
≥95%
Formulation
A 1 mg/ml solution in methanol
SMILES
O=C(C)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1
InChi Key
AURFZBICLPNKBZ-SYBPFIFISA-N
Regulatory Information
DEA Exempt Notification
This product is a DEA exempt preparation of a scheduled compound - does not require DEA Controlled Substance registration or DEA 222 form. For alternate sizes please contact sales.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $83

    Add
    Cayman Chemical
    Cayman Spectral Library

    Our free, searchable, GC-MS spectral database contains 70eV EI mass spectral data of 2,000+ of Cayman’s forensic drug standards.

    DOWNLOAD THE DATABASE
    Product Description

    Allopregnanolone (exempt preparation) (Item No. 43516) is an analytical reference standard categorized as a GABAA and GABAC receptor positive allosteric modulator.1,2 Allopregnanolone has anxiolytic-like and anticonvulsant activities in rodents.3,4 Formulations containing allopregnanolone have been used in the treatment of postpartum depression. Allopregnanolone is regulated as a Schedule IV compound in the United States. Allopregnanolone (exempt preparation) (Item No. 43516) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alvarez, L.D., Pecci, A., and Estrin, D.A. In search of GABAA receptor’s neurosteroid binding sites. J. Med. Chem. 62(11), 5250-5260 (2019).

    2. Johnston, G.A.R., Chebib, M., Hanrahan, J.R., et al. Neurochemicals for the investigation of GABAC receptors. Neurochem. Res. 35(12), 1970-1977 (2010).

    3. Fernández-Guasti, A., and Picazo, O. Flumazenil blocks the anxiolytic action of allopregnanolone. Eur. J. Pharmacol. 281(1), 113-115 (1995).

    4. Reddy, D.S., Castaneda, D.C., O'Malley, B.W., et al. Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. J. Pharmacol. Exp. Ther. 10(1), 230-239 (2004).