A triterpenoid with anticancer activity
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Lucidenic Acid B

Item No. 43524

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5α,7β,12β)-7,12-dihydroxy-4,4,14-trimethyl-3,11,15-trioxo-chol-8-en-24-oic acid
CAS Number
95311-95-8
Molecular Formula
C27H38O7
Formula Weight
474.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C[C@]1([H])[C@@H](CCC(O)=O)C)[C@@]([C@]1(C)[C@H](O)C2=O)(C)C3=C2[C@]4(C)[C@](C[C@@H]3O)([H])C(C)(C)C(CC4)=O
InChi Code
InChI=1S/C27H38O7/c1-13(7-8-19(31)32)14-11-18(30)27(6)20-15(28)12-16-24(2,3)17(29)9-10-25(16,4)21(20)22(33)23(34)26(14,27)5/h13-16,23,28,34H,7-12H2,1-6H3,(H,31,32)/t13-,14-,15+,16+,23-,25+,26+,27+/m1/s1
InChi Key
GYRDSOABOBCYST-HFAARYGVSA-N
Origin
Fungus/Ganoderma sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $193

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    5 mg

    $434

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    10 mg

    $675

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    Product Description

    Lucidenic acid B is a triterpenoid that has been found in G. lucidum and has anticancer activity.1,2,3 It inhibits Epstein-Barr virus early antigen production induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji Burkitt lymphoma cells.1 Lucidenic acid B inhibits the growth of COLO 205, HepG2, HL-60, and HT-29 cancer cells (IC50s = 249, 112, 19.3, and 382 µM, respectively) and induces apoptosis in HL-60 leukemia cells when used at concentrations ranging from 5 to 100 µM.2 It also inhibits TPA-induced invasion of HepG2 cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akihisa, T., Nakamura, Y., Tagata, M., et al. Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum. Chem. Biodivers. 4(2), 224-231 (2007).

    2. Hsu, C.-L., Yu, Y.-S., and Yen, G.-C. Lucidenic acid B induces apoptosis in human leukemia cells via a mitochondria-mediated pathway. J. Agric. Food Chem. 56(11), 3973-3980 (2008).

    3. Weng, C.-J., Chau, C.-F., Chen, K.-D., et al. The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain. Mol. Nutr. Food Res. 51(12), 1472-1477 (2007).