A Cav3.2 and Cav3.3 inhibitor
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ML-218

Item No. 43541

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-dichloro-N-[[(1α,5α,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide
CAS Number
1346233-68-8
Molecular Formula
C19H26Cl2N2O
Formula Weight
369.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
[H][C@]12CN(C[C@@]([C@@H]2CNC(C3=CC(Cl)=CC(Cl)=C3)=O)1[H])CCC(C)(C)C
InChi Code
InChI=1S/C19H26Cl2N2O/c1-19(2,3)4-5-23-10-16-15(17(16)11-23)9-22-18(24)12-6-13(20)8-14(21)7-12/h6-8,15-17H,4-5,9-11H2,1-3H3,(H,22,24)/t15-,16-,17+
InChi Key
GSJIGYLGKSBYBC-OSYLJGHBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $149

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    10 mg

    $253

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    25 mg

    $483

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    50 mg

    $669

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    Product Description

    ML-218 is an inhibitor of T-type voltage-gated calcium channel 3.2 (Cav3.2) and Cav3.3.1 It inhibits currents in whole-cell patch clamp assays using HEK293 cells expressing Cav3.2 or Cav3.3 (IC50s = 310 and 274 nM, respectively). ML-218 (0.1-30 mg/kg) decreases the latency to paw withdrawal in a rat model of catalepsy induced by haloperidol (Item No. 12014).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiang, Z., Thompson, A.D., Brogan, J.T., et al. The discovery and characterization of ML218: A novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson’s Disease. ACS Chem. Neurosci. 2(12), 730-742 (2011).