An SM-102-based LNP solution for knockdown of hINHBE in vitro
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LipidLaunch™ SM-102 LNP (siRNA hINHBE)

Item No. 43543

Product Insert (PDF)
Technical Information
Synonyms
  • Inhibin Beta E Chain
  • LipidLaunchTM SM-12 Lipid Nanoparticle (siRNA hINHBE)
Formulation (Request formulation change)
TBS, pH 7.5, with 10% sucrose
UniProt Accession №
P58166
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    5 µg

    $359

    Add
    Cayman Chemical
    Product Description

    LipidLaunch™ SM-102 LNP (siRNA hINHBE) is a solution containing lipid nanoparticles (LNPs) composed of the ionizable cationic amino lipid SM-102 (Item No. 33474), cholesterol (Item No. 9003100), 1,2-distearoyl-sn-glycero-3-PC (DSPC; Item No. 15100), and the lipid excipient DMG-PEG(2000) (Item No. 33945) at a molar ratio of 50:38.5:10:1.5 and encapsulating siRNA targeting human inhibin beta E chain (hINHBE), a hepatokine involved in hepatocyte viability, thermogenesis, and insulin sensitivity.1,2,3 It is intended for use in the knockdown of hINHBE in vitro and can be used in any cells expressing hINHBE.

    Suggested in vitro use: Thaw LNPs on ice with occasional gentle swirling (do not vortex). Using a gentle pipetting technique, dilute 1:100-1:500 in complete cell culture media (with serum) and add to subconfluent cells. Knockdown of INHBE may be detected between six and 48 hours after transfection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wada, W., Medina, J.J., Kuwano, H., et al. Comparison of the function of the βC and βE subunits of activin in AML12 hepatocytes. Endocr. J. 52(2), 169-175 (2005).

    2. Hashimoto, O., Funaba, M., Sekiyama, K., et al. Activin E controls energy homeostasis in both brown and white adipose tissues as a hepatokine. Cell Rep. 25(5), 1193-1203 (2018).

    3. Hashimoto, O., Tsuchida, K., Ushiro, Y., et al. cDNA cloning and expression of human activin βE subunit. Mol. Cell. Endocrinol. 194(1-2), 117-122 (2002).