An immunosuppressant
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MNITMT

Item No. 43554

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methyl-3-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-4H-1,2,4-triazole
CAS Number
177653-76-8
Synonyms
  • NSC 631156
Molecular Formula
C7H8N6O2S
Formula Weight
240.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
CN1C(SC2=C([N+]([O-])=O)N=CN2C)=NN=C1
InChi Code
InChI=1S/C7H8N6O2S/c1-11-3-8-5(13(14)15)6(11)16-7-10-9-4-12(7)2/h3-4H,1-2H3
InChi Key
NMBDIMPYACLUDE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $60

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    10 mg

    $114

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    25 mg

    $238

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    50 mg

    $416

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    Product Description

    MNITMT is an immunosuppressant.1 It inhibits cell proliferation in the human mixed lymphocyte reaction (EC50 = 2.7 µM). MNITMT (45 mg/kg per day) increases allograft survival in a mouse skin transplantation model. It also inhibits the human IgG-induced antibody response in rabbits when administered at a dose of 2 mg/kg per day.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Crawford, D.J., Maddocks, J.L., Jones, D.N., et al. Rational design of novel immunosuppressive drugs: Analogues of azathioprine lacking the 6-mercaptopurine substituent retain or have enhanced immunosuppressive effects. J. Med. Chem. 39(14), 2690-2695 (1996).

    2. Al-Safi, S., Tashtoush, B., and Hassan, M. Comparison of the effects of azathioprine and its novel non-mercaptopurine analog on antibody response in rabbits. Pol. J. Pharmacol. 55(2), 239-243 (2003).