An Aster-A inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Autogramin-2

Item No. 43556

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7-dihydro-2-[[4-(1-methylethoxy)benzoyl]amino]-thiazolo[5,4-c]pyridine-5(4H)-carboxylic acid, 1,1-dimethylethyl ester
CAS Number
2375541-45-8
Molecular Formula
C21H27N3O4S
Formula Weight
417.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CC(OC1=CC=C(C(NC2=NC(CCN(C(OC(C)(C)C)=O)C3)=C3S2)=O)C=C1)C
InChi Code
InChI=1S/C21H27N3O4S/c1-13(2)27-15-8-6-14(7-9-15)18(25)23-19-22-16-10-11-24(12-17(16)29-19)20(26)28-21(3,4)5/h6-9,13H,10-12H2,1-5H3,(H,22,23,25)
InChi Key
PNSFNXURLSDVRV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $61

    Add

    10 mg

    $109

    Add

    25 mg

    $227

    Add

    50 mg

    $394

    Add
    Product Description

    Autogramin-2 is an inhibitor of Aster-A (IC50 = 1.93 µM), a protein that transports cholesterol from the plasma membrane to the endoplasmic reticulum (ER).1 Autogramin-2 is selective for Aster-A over Aster-B and -C (IC50s = >20 µM for both). It inhibits autophagy induced by amino acid starvation or rapamycin-mediated mammalian target of rapamycin 1 (mTORC1) inhibition in MCF-7 cells (IC50s = 0.27 and 0.14 µM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Whitmarsh-Everiss, T., Olsen, A.H., and Laraia, L. Identification of inhibitors of cholesterol transport proteins through the synthesis of a diverse, sterol-inspired compound collection. Angew. Chem. Int. Ed. Engl. 60(51), 26755-26761 (2021).

    2. Laraia, L., Friese, A., Corkery, D.P., et al. The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis. Nat. Chem. Biol. 15(7), 710-720 (2019).