A DDX9 inhibitor

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Product Categories

Product Type

Small Molecule Modulators

Small Molecule Inhibitors

Research Area

Cancer

DHX9-IN-6

Name: DHX9-IN-6
Brand: -

Item No. 43559

DHX9-IN-6 (DEAD-box Helicase 9-IN-6, DEAD-box Helicase 9 Inhibitor 6, DHX9 Inhibitor 6, CAS Number: 2973401-56-6)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

N-[3-chloro-5-[(methylsulfonyl)amino]phenyl]-4-[3-[(5-fluoro-3-pyridinyl)methoxy]-2-pyridinyl]-2-thiophenecarboxamide

CAS Number

2973401-56-6

Synonyms

DEAD-box Helicase 9-IN-6
DEAD-box Helicase 9 Inhibitor 6
DHX9 Inhibitor 6

Molecular Formula

C₂₃H₁₈ClFN₄O₄S₂

Formula Weight

533.0

Purity

≥98%

Formulation

A solid

Solubility(Learn about Variance in Solubility)

DMSO: Sparingly soluble: 1-10 mg/ml

SMILES

O=C(C1=CC(C(N=CC=C2)=C2OCC3=CN=CC(F)=C3)=CS1)NC4=CC(N[S](C)(=O)=O)=CC(Cl)=C4

InChi Code

InChI=1S/C23H18ClFN4O4S2/c1-35(31,32)29-19-8-16(24)7-18(9-19)28-23(30)21-6-15(13-34-21)22-20(3-2-4-27-22)33-12-14-5-17(25)11-26-10-14/h2-11,13,29H,12H2,1H3,(H,28,30)

InChi Key

NPHAXUSEUGJGNE-UHFFFAOYSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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1 mg

$357

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5 mg

$1,604

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Product Description

DHX9-IN-6 is an inhibitor of DEAD-box helicase 9 (DDX9; IC₅₀ = 0.32 µM).¹ It reduces the proliferation of LS411N colorectal cancer cells (IC₅₀ = 0.0264 µM).

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Daniels, M.H., Duncan, K.W., Sparling, B.A., et al. Inhibitors of RNA helicase DHX9 and uses thereof. (2023).

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