An internal standard for the quantification of spironolactone
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Spironolactone-d3

Item No. 43592

Product Insert (PDF)
Technical Information
Formal Name
(7α,17α)-7-(acetylthio-d3)-17-hydroxy-3-oxo-pregn-4-ene-21-carboxylic acid-γ-lactone
Synonyms
  • SC-9420-d3
Molecular Formula
C24H29D3O4S
Formula Weight
419.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: SolubleMethanol: Soluble
SMILES
O=C(CC1)O[C@@]21CC[C@@]3([H])[C@]4([H])[C@H](SC(C([2H])([2H])[2H])=O)CC5=CC(CC[C@]5(C)[C@@]4([H])CC[C@@]32C)=O
InChi Code
InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1/i1D3
InChi Key
LXMSZDCAJNLERA-OFUZVNSWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $600

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    Product Description

    Spironolactone-d3 is intended for use as an internal standard for the quantification of spironolactone by GC- or LC-MS. Spironolactone is a steroidal mineralocorticoid receptor antagonist (IC50 = 24 nM) and a diuretic.1 It is selective for the mineralocorticoid receptor over the glucocorticoid receptor (IC50 = 2,410 nM) but also binds to the androgen receptor and progesterone receptor (IC50s = 77 and 743 nM, respectively). In vivo, spironolactone (37.5 mg/kg per day) administered in combination with lisinopril preserves ejection fraction in mice and reduces myocardial fibrosis in a mouse model of Duchenne muscular dystrophy (DMD).2 Formulations containing spironolactone have been used in the treatment of hypertension and heart failure.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kolkhof, P., Jaisser, F., Kim, S.-Y., et al. Steroidal and novel non-steroidal mineralocorticoid receptor antagonists in heart failure and cardiorenal diseases: Comparison at bench and bedside. Handb. Exp. Pharmacol. 243, 271-305 (2017).

    2. Rafael-Fortney, J.A., Chimanji, N.S., Schill, K.E., et al. Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice. Circulation 124(5), 582-588 (2011).