A PAF-AH inhibitor
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Rilapladib

Item No. 43593

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(2,3-difluorophenyl)methyl]thio]-N- [1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]methyl]-1(4H)-quinolineacetamide
CAS Number
412950-08-4
Synonyms
  • SB 659032
Molecular Formula
C40H38F5N3O3S
Formula Weight
735.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
COCCN1CCC(N(C(CN(C(SCC2=C(C(F)=CC=C2)F)=C3)C4=C(C=CC=C4)C3=O)=O)CC(C=C5)=CC=C5C6=CC=C(C=C6)C(F)(F)F)CC1
InChi Code
InChI=1S/C40H38F5N3O3S/c1-51-22-21-46-19-17-32(18-20-46)47(24-27-9-11-28(12-10-27)29-13-15-31(16-14-29)40(43,44)45)37(50)25-48-35-8-3-2-6-33(35)36(49)23-38(48)52-26-30-5-4-7-34(41)39(30)42/h2-16,23,32H,17-22,24-26H2,1H3
InChi Key
NNBGCSGCRSCFEA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $303

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    10 mg

    $515

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    25 mg

    $757

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    Product Description

    Rilapladib is an inhibitor of platelet-activating factor acetylhydrolase (PAF-AH), also known as lipoprotein-associated phospholipase A2 (Lp-PLA2; IC50 = 230 pM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shaddinger, B.C., Xu, Y., Roger, J.H., et al. Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: Results from an in vitro study and two randomized phase I trials. PLoS One 9(1), e83094 (2014).